ABSTRACT
To evaluate treatment results and toxicities in patients who received concomitant chemoradiotherapy [CRT] followed by consolidation with docetaxel and cisplatin in locally advanced unresectable non-small cell lung cancer [NSCLC]. Ninety three patients were included in this retrospective study. The patients received 66 Gy radiotherapy and weekly 20 mg/m[2] docetaxel and 20 mg/m[2] cisplatin chemotherapy concomitantly. One month later than the end of CRT, consolidation chemotherapy with four cycles of docetaxel 75 mg/m[2] and cisplatin 75 mg/m[2] were administered at each 21 days. Median age of the patients was 57 [range, 30-74]. Following concomitant CRT, 14 patients [15%] showed complete and 50 patients [54%] showed partial response [total response rate was 69%]. The median follow-up was 13 months [range: 2-51 months]. The median overall survival was 18 months [95% confidential interval [Cl]: 13.8-22.1 months]; local control was 15 months [95% Cl: 9.3-20.6 months]; progression-free survival was 9 months [95% Cl: 6.5-11.4 months]. Esophagitis in eight [9%] patients, neutropenia in seven [8%] patients and pneumonitis in eight [9%] patients developed as grade III-IV toxicity due to concomitant CRT. Concomitant CRT with docetaxel and cisplatin followed by docetaxel and cisplatin consolidation chemotherapy might be considered as a feasible, and well tolerated treatment modality with high response rates despite the fact that it has not a survival advantage in patients with locally advanced unresectable NSCLC